Assuntos
Diabetes Mellitus Tipo 2/fisiopatologia , Resistência à Insulina/fisiologia , Adulto , Albuminúria/epidemiologia , Diabetes Mellitus Tipo 2/tratamento farmacológico , Diabetes Mellitus Tipo 2/epidemiologia , Europa (Continente)/epidemiologia , Feminino , Humanos , Hipercolesterolemia/epidemiologia , Hiperlipidemias/epidemiologia , Hipertrigliceridemia/epidemiologia , Hipoglicemiantes/uso terapêutico , Masculino , Metformina/uso terapêutico , Pessoa de Meia-Idade , Obesidade/epidemiologia , Fatores de Risco , Espanha/epidemiologiaRESUMO
The experience of the Preconceptional Clinic developed in our hospital from 1992 to 1996 is here reported. Twenty-eight insulin-dependent diabetic patients underwent a preconceptional control (PCC). Pregnancy was obtained in 19 patients (2 miscarriages, 12 full pregnancies, and 5 pregnancies in course). A comparative case-control study was performed between the 12 patients undergoing PCC, who have completed their pregnancy, and other 12 prepregnant diabetic patients, controlled from the 7-12 weeks of pregnancy. HbA1c levels in the PCC group were lower, and no differences regarding fetal morbidity were observed. The presence of a severe congenital malformation in the PCC group, with normal periconceptional HbA1c levels, denotes the teratogenic influence of factors yet to be elucidated.
Assuntos
Diabetes Mellitus Tipo 1/prevenção & controle , Cuidado Pré-Concepcional , Resultado da Gravidez , Gravidez em Diabéticas/prevenção & controle , Adulto , Diabetes Mellitus Tipo 1/sangue , Feminino , Hemoglobinas Glicadas/metabolismo , Humanos , Gravidez , Gravidez em Diabéticas/sangueRESUMO
OBJECTIVE: The objective of this study was to determine the incidence of macrosomia in infants of diabetic mothers (IDM) and to analyze its possible correlation with insulin, C-peptide, growth hormone (GH) and IGF-I levels in umbilical cord blood. PATIENTS AND METHODS: A prospective study of 58 IDM and 58 control newborns (33 males and 25 females in both groups) was carried out. RESULTS: The incidence of macrosomia was 25.8% in the IDM group and 61.5% in the IIDDM group (infant of insulin-dependent diabetic mother) compared to 5% in the control group. There was a positive correlation between maternal Hgb Alc levels in the third trimester of gestation and insulin and C-peptide levels with newborn weight in the IDM group (especially in the IIDDM group). IGF-I levels were positively correlated with newborn weight in both control and IDM groups. There was no correlation between GH and IGF-I levels in any group.
Assuntos
Desenvolvimento Infantil , Diabetes Mellitus Tipo 2 , Macrossomia Fetal/sangue , Hormônio do Crescimento Humano/sangue , Peptídeo C/sangue , Feminino , Sangue Fetal/química , Macrossomia Fetal/epidemiologia , Hemoglobinas/análise , Humanos , Incidência , Recém-Nascido , Insulina/sangue , Masculino , Estudos ProspectivosRESUMO
OBJECTIVE: The objective of this study was to determine fibronectin levels in umbilical cord blood of infants of diabetic mothers (IDM) and evaluate a possible correlation with perinatal pathology. PATIENTS AND METHODS: A prospective study of 58 IDM (33 males and 25 females) and 58 control newborns (NB) (33 males and 25 females) was carried out. RESULTS: There were no differences in fibronectin levels between the two groups nor between the sexes. Perinatal morbidity was higher in the IDM group, but there was no correlation between fibronectin levels and the presence of perinatal pathology. CONCLUSIONS: Fibronectin levels are not useful in the perinatal evaluation of infants of diabetic mothers.
